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Target Organs and Levels of Evidence for TR-205

Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4,4'-Oxydianiline
101-80-4
02/15/1980Chemical intermediate for polyimide and poly(ester-imide) resins. 4,4'-Oxydianiline is used in the manufacture of high temperature resistant metal adhesives, molding and machine parts, and insulators.Dosed-Feed
R: 0,200,400,500, M: 0,150,300,800 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: (ADENOMA)
  • Liver: (ADENOMA OR CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: (ADENOMA)
  • Liver: (CARCINOMA)
  • Thyroid Gland Follicular Cell: ADENOMA