National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9798

Target Organs and Levels of Evidence for TR-219

Carcinogenesis Bioassay of 2,6-Dichloro-p-Phenylenediamine (CASRN 609-20-1) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,6-Dichloro-p-phenylenediamine
609-20-1
10/15/1980Intermediate in manufacture of polyamide fiber; a polyurethane curativeDosed-Feed
FR: 0,2000,6000, MR: 0,1000,2000, M: 0,1000,3000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 7/50 15/50
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 4/50 9/50 OR CARCINOMA 2/50 2/50 7/50


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.