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Target Organs and Levels of Evidence for TR-237

Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,1,1,2-Tetrachloroethane
630-20-6
12/16/1981Intermediate for producing tri- and tetra- chloroethyleneGavage
R: 0,125,250, M: 0,250,500 MG/KG/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 0/49 1/49 2/48 OR CARCINOMA 0/49 0/49 1/48 COMBINED 0/49 1/49 3/48
Non-Neoplastic Lesions
  • KIDNEY: MINERALIZATION
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/48 14/46 21/50
Non-Neoplastic Lesions
  • LIVER: INFLAMMATION; NECROSIS; CYTOMEGALY; FATTY METAMORPHOSIS
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/49 8/46 24/48 OR CARCINOMA 1/49 5/46 6/48 COMBINED 5/49 13/46 30/48
Non-Neoplastic Lesions
  • LIVER: INFLAMMATION; NECROSIS; CYTOMEGALY; FATTY METAMORPHOSIS