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https://ntp.niehs.nih.gov/go/7154

bis(2-Chloro-1-methylethyl) ether: Target Organs and Levels of Evidence for TR-239

Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CASRN 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CASRN 83270-31-9) in B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
bis(2-Chloro-1-methylethyl) ether
108-60-1
12/16/1981Paint & varnish removers; intermediate in dyes, resins and pharmaceuticals; nematocide in JapanGavage
0,100,200 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 13/50 11/50
  • Liver: CARCINOMA 5/50 13/50 17/50
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/50
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/49 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/49 1/49 COMBINED 0/50 0/49 2/49