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Target Organs and Levels of Evidence for TR-240

Carcinogenesis Bioassay of Propyl Gallate (CASRN 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Propyl gallate
121-79-9
12/16/1981Antioxidant in foods containing fats/oils, food packaging materials, and cosmetics. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
0,6000,12000 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Preputial Gland: ADENOMA 0/50 5/50 0/50; ADENOMA, ADENOCARCINOMA 0/50 3/50 0/50, OR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 8/50 0/50
  • Pancreas Islet Cell: ADENOMA 0/50 8/50 2/50 ADENOMA OR CARCINOMA 2/50 1/50 2/50 COMBINED 2/50 9/50 4/50
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 4/50 13/48 8/50
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 1/50 3/49 8/50
Female Mice: Negative