National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7162

Target Organs and Levels of Evidence for TR-244

Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Polybrominated biphenyl mixture (Firemaster FF-1)
67774-32-7
06/23/1981Major use as flame retardant for synthetic fibers & plasticsGavage
0,0.1,0.3,1.0,3.0,10.0 MG/KG/50 PER GROUP
National Institute of Env. Health Sciences

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8


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