National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7588

Target Organs and Levels of Evidence for TR-252

Carcinogenesis Studies of Food Grade Geranyl Acetate (71% Geranyl Acetate, 29% Citronellyl Acetate) (CASRN 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Geranyl acetate
105-87-3
09/22/1982Fragrance in cosmetic creams, lotions, perfumes, soaps and detergents. Flavor in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,1000,2000, M: 0,500,1000 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Negative
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Skin: SQUAMOUS CELL PAPILLOMA 0/50 4/50 1/50
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 0/50
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.