National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7604

Target Organs and Levels of Evidence for TR-267

Toxicology and Carcinogenesis Studies of Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Propylene oxide
75-56-9
06/29/1983Intermediate in production of polyether polyols, polyurethane foams, and unsaturated polyester resins; fumigant for medical instruments and foodstuffs. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,200,400 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, SUPPURATIVE; HYPERPLASIA, EPITHELIAL; METAPLASIA, SQUAMOUS
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA 0/50 0/50 3/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, SUPPURATIVE; HYPERPLASIA, EPITHELIAL; METAPLASIA, SQUAMOUS
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Nasal Cavity): HEMANGIOMA 0/50 0/50 5/50; HEMANGIOSARCOMA 0/50 0/50 5/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, SUPPURATIVE
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Nasal Cavity): HEMANGIOMA 0/50 0/50 3/50; HEMANGIOSARCOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION, SUPPURATIVE


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