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Target Organs and Levels of Evidence for TR-299

Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CASRN 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Disperse blue 1
2475-45-8
03/29/1985Dye for sheepskins, furs, thermoplastic resins, acetate, nylon (HSDB 1990); also a component of several semipermanent hair dyes (TR-299, 1986)Dosed-Feed
R: 0,12500,2500,5000, M: 0,600,1200,2500 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49
May Have Been Related
  • Pancreas Islet Cell: ADENOMA 1/49 0/50 4/50 2/50 OR CARCINOMA 0/49 2/50 1/50 1/50 COMBINED 1/49 2/50 5/50 3/50
Non-Neoplastic Lesions
  • URINARY BLADDER: CALCULI
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48
Non-Neoplastic Lesions
  • URINARY BLADDER: CALCULI
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/50 9/50 10/50 9/50 OR CARCINOMA 6/50 15/50 13/50 8/50 COMBINED 9/50 21/50 20/50 16/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/49 5/50 5/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 6/49 1/50 6/50 COMBINED 4/50 9/49 5/50 11/50
Female Mice: No Evidence