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Target Organs and Levels of Evidence for TR-314

Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyl methacrylate
80-62-6
12/09/1985In manufacture of methacrylate resins & plastics, in impregnation of concrete, monomer, comonomer, intermediate, occurs in oil from roman chamomile (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
FR: 0,250,500, MR&M: 0,500,1000 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION; DEGENERATION, EPITHELIAL
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION; DEGENERATION, EPITHELIAL
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION; DEGENERATION, EPITHELIAL; HYPERPLASIA, EPITHELIAL
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: INFLAMMATION; DEGENERATION, EPITHELIAL; HYPERPLASIA, EPITHELIAL