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Target Organs and Levels of Evidence for TR-323

Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Dimethyl methylphosphonate
756-79-6
08/19/1986Flame retardant; solvent; hydraulic fluid; antifoam agent; plasticizer and stabilizer; textile conditioner and antistatic agentGavage
R: 0,500,1000, M: 0,1000,2000 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: PAPILLOMA 0/50 7/50 3/49
  • Kidney Tubular Cell: ADENOCARCINOMA 0/50 2/50 3/49
May Have Been Related
  • Hematopoietic System: LEUKEMIA 10/50 11/50 17/50
Non-Neoplastic Lesions
  • KIDNEY: HYPERPLASIA, TUBULAR CELL 0/50 8/50 9/49; HYPERPLASIA, EPITHELIAL 0/50 23/50 21/49
Female Rats: No Evidence
Male Mice: Inadequate Study
Female Mice: No Evidence