National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13730

Target Organs and Levels of Evidence for TR-327

Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CASRN 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Xylenes (mixed)
1330-20-7
03/26/1986Solvent, component of gasoline, protective coatings, in manufacture of dyes, pharmaceuticals, perfumes, pesticides, paints, adhesives, indirect food additive for use as component of adhesives. A solvent, cleaning agent, degreaser & is a constituent of aviation & automobile fuels. Used in the production of benzoic acid, phthalate anhydride, & isophthalic & terephthalic acids & their dimethyl esters. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: No Evidence


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