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Target Organs and Levels of Evidence for TR-335

Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Acid orange 3
6373-74-6
07/14/1987Dyeing acetate, wool, nylon, silk, and leather; shading component in soaps and wood stains. A dinitrodiphenylamine derivative used in semipermanent hair coloring products.Gavage
R: 0,375,750 MG/KG MM: 0,125,250 MG/KG FM: 0,250,500 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 37/50 44/50; PIGMENTATION 4/50 4/50 39/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 6/50 13/50
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA 0/50 0/50 6/50
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 0/50 10/50 45/50; PIGMENTATION 0/50 0/50 5/50; HYPERPLASIA, EPITHELIAL, PELVIC 0/50 2/50 13/50; NEPHROPATHY 23/50 45/50 48/50; NECROSIS, PAPILLA 0/50 0/50 10/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 1/50 4/50 12/50; FIBROSIS 0/50 5/50 19/50; NECROSIS 0/50 0/50 7/50; DEGENERATION, PAPILLA 0/50 4/50 18/50; DILATATION, TUBULE 2/50 39/50 33/50
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INFLAMMATION, SUPPURATIVE 7/50 7/50 22/50; FIBROSIS 4/50 9/50 31/50; NECROSIS 2/50 5/50 8/50; DEGENERATION, PAPILLA 0/50 3/50 19/50; DILATATION, TUBULE 2/50 35/50 42/50; NEPHROSIS 13/50 42/50 50/50; MINERALIZATION, TUBULE 3/50 15/50 22/50