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Target Organs and Levels of Evidence for TR-340

Toxicology and Carcinogenesis Studies of Iodinated Glycerol (Organidin®) (CASRN 5634-39-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Iodinated glycerol
5634-39-9
10/04/1988Mucolytic-expectorant in respiratory tract conditions. Gavage
FR&FM: 0, 62, 125, MR&MM: 0, 125, 250 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 14/50 29/50 24/50
  • Thyroid Gland Follicular Cell: CARCINOMA 0/49 5/49 1/49
May Have Been Related
  • Nasal Cavity: ADENOMA 0/48 0/47 2/49
Non-Neoplastic Lesions
  • SALIVARY GLAND: ATROPHY, FOCAL 1/48 10/50 30/49; METAPLASIA, SQUAMOUS 0/48 47/50 48/49
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SALIVARY GLAND: ATROPHY, FOCAL 0/49 4/50 11/50; METAPLASIA, SQUAMOUS 1/49 48/50 49/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL 3/48 46/50 34/50; DILATATION, FOLLICLE 0/48 28/50 32/50
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 10/47 15/45 24/46
  • Harderian Gland: ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49
Non-Neoplastic Lesions
  • THYROID GLAND: HYPERPLASIA, FOLLICULAR CELL 2/48 25/48 35/48; DILATATION, FOLLICLE 4/48 11/48 10/48