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Target Organs and Levels of Evidence for TR-346

Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chloroethane
75-00-3
10/03/1988This compound is used in the manufacture of tetraethyl lead, ethyl cellulose, sulfanol and trional; as an anesthetic; in organic synthesis; as an alkylating agent; in refrigeration; as an analytical reagent; as a solvent for phosphorous , sulfur, fats, oils, resins and waxes; in insecticides; and as an ethylating agent in the manufacture of dyes and drugs (Radian H&S, 1991). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R&M: 0, 15000 PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: TRICHOEPITHELIOMA 0/49 1/46, SEBACEOUS GLAND ADENOMA 0/49 1/46, OR BASAL CELL CARCINOMA 0/49 3/46 COMBINED 0/49 5/46
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Brain: ASTROCYTOMA 0/50 3/50
Male Mice: Inadequate Study
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Uterus/Cervix: ENDOMETRIAL CARCINOMA 0/49 43/50
May Have Been Related
  • Liver: ADENOMA 0/49 1/48 OR CARCINOMA 3/49 7/48 COMBINED 3/49 8/48