National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8935

Target Organs and Levels of Evidence for TR-369

Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
alpha-Methylbenzyl alcohol
98-85-1
03/13/1989Flavoring agent. Fragrances. Lab reagent. Intermediate in styrene production. Dyes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&M: 0, 375, 750 MG/KG/50 PER GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY; HYPERPLASIA, TUBULAR CELL 0/50 4/50 4/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: MILD NEPHROPATHY
Male Mice: No Evidence
Female Mice: No Evidence


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.