Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/9480

3,3'-Dimethoxybenzidine dihydrochloride: Target Organs and Levels of Evidence for TR-372

Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3,3'-Dimethoxybenzidine dihydrochloride
20325-40-0
06/27/1989Production of dyesDosed-Water
R: 0,80,170,330 PPM /70,45,75,70 PER GROUP RESPECTIVELY
Hazleton, Vienna

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60
  • Liver: NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60
  • Large Intestines: ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60
  • Zymbal Gland: ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60
  • Preputial Gland: ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA 2/60 1/45 7/75 6/60
May Have Been Related
  • Brain: ASTROCYTOMA 0/60 2/44 3/75 1/60
Non-Neoplastic Lesions
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION 3/60 13/42 43/74 38/59
  • LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC 0/60 3/44 10/75 6/60
  • HEART: ATRIUM, THROMBUS 3/60 15/44 27/75 23/60
  • LIVER: DEGENERATION, CYSTIC 13/60 23/45 34/74 28/60; DEGENERATION, CENTRILOBULAR, DIFFUSE 0/60 4/45 9/74 10/60; NECROSIS, CENTRILOBULAR 4/60 13/45 10/74 6/60
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Zymbal Gland: ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60
  • Clitoral Gland: ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55
  • Mammary Gland: ADENOCARCINOMA 1/60 2/45 14/75 20/60
  • Skin: SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60
  • Large Intestines: ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60
  • Liver: NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60
  • Uterus/Cervix: ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59
Non-Neoplastic Lesions
  • LUNG: INFILTRATION, CELLULAR, HISTIOCYTIC 0/60 3/45 4/75 18/60
  • LIVER: DEGENERATION, CYSTIC 1/60 2/44 1/75 5/60; DEGENERATION, CENTRILOBULAR 1/60 3/44 8/75 5/60; NECROSIS CENTRILOBULAR 1/60 2/44 6/75 5/60
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION 3/60 22/44 50/75 47/60