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Target Organs and Levels of Evidence for TR-385

Toxicology and Carcinogenesis Studies of Methyl Bromide (CASRN 74-83-9) in B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyl bromide
74-83-9
11/19/1990Fumigant, extractant, wool degreasing, in ion. Chambers, fire-extinguishing agent, insecticide, rodenticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
MICE ONLY:0,10,33,100 PPM
Brookhaven National Lab (DOE)

Levels of Evidence

Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: DEGENERATIVE CHANGES IN CEREBELLUM AND CEREBRUM
  • HEART: MYOCARDIAL DEGENERATION AND CARDIOMYOPATHY
  • BONE: STERNAL DYSPLASIA
  • NOSE: OLFACTORY EPITHELIAL NECROSIS AND METAPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: DEGENERATIVE CHANGES IN CEREBELLUM AND CEREBRUM
  • HEART: MYOCARDIAL DEGENERATION AND CARDIOMYOPATHY
  • BONE: STERNAL DYSPLASIA
  • NOSE: OLFACTORY EPITHELIAL NECROSIS AND METAPLASIA


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyl bromide
74-83-9
Fumigant, extractant, wool degreasing, in ion. Chambers, fire-extinguishing agent, insecticide, rodenticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0,30,120, M: 0,10,120 PPM/10 PER GROUP
Brookhaven National Lab (DOE)

Levels of Evidence