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Target Organs and Levels of Evidence for TR-386

Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetranitromethane
509-14-8
11/20/1989Rocket propellants; additive to diesel fuel; explosive; reagent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP
Midwest Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA, SQUAMOUS METAPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC; RESPIRATORY EPITHELIUM, HYPERPLASIA LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50
Non-Neoplastic Lesions
  • NASAL CAVITY: MUCOSA, INFLAMMATION, CHRONIC LUNG: ALVEOLAR-BRONCHIOLAR HYPERPLASIA