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https://ntp.niehs.nih.gov/go/10985

Target Organs and Levels of Evidence for TR-407

Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Pigment red 3
2425-85-6
07/09/1991Used in manufacture of paints, inks, plastics, and rubber. Dosed-Feed
R: 0, 6000, 12500, 25000; M: 0, 12500, 25000, 50000 PPM (60 PER GROUP)
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50
May Have Been Related
  • Skin: SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50
  • Zymbal Gland: CARCINOMA 0/50 0/50 2/50 3/50
Non-Neoplastic Lesions
  • LIVER: FOCAL CELLULAR ALTERATIONS
  • KIDNEY: NEPHROPATHY, CHRONIC
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 22/50 6/50 2/50 1/50
  • PREPUTIAL GLAND: ADENOMA 6/49 0/13 1/25 1/50 OR CARCIN0MA 1/49 0/13 0/25 0/50 COMBINED 7/49 0/13 1/25 1/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 0/50 1/50 10/50
Non-Neoplastic Lesions
  • LIVER: FOCAL CELLULAR ALTERATIONS
  • KIDNEY: NEPHROPATHY, CHRONIC
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 10/50 1/50 0/50 2/50
  • CLITORAL GLAND: ADENOMA 9/47 1/14 0/14 1/50
  • MAMMARY GLAND: FIBROADENOMA 23/50 16/50 20/49 12/50
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 0/50 6/50
  • Thyroid Gland Follicular Cell: ADENOMA 0/50 0/49 1/50 5/50
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY, CHRONIC; RENAL TUBULE, EPITHELIUM, CYTOMEGALY.
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY, CHRONIC
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA