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https://ntp.niehs.nih.gov/go/10495

Target Organs and Levels of Evidence for TR-423

Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3,4-Dihydrocoumarin
119-84-6
06/23/1992Fragrance in cosmetics and detergents. Flavoring agent in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,150,300,600, M: 0,200,400,800 MG/KG/50 PER GROUP
American Biogenics Corp (Bioassay Systems)

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50
May Have Been Related
  • Kidney Transitional Cell: CARCINOMA 0/50 0/48 0/47 2/50
Non-Neoplastic Lesions
  • FORESTOMACH: ULCER; HYPERPLASIA; INFLAMMATION
  • PARATHYROID GLAND: HYPERPLASIA
  • KIDNEY: TUBULAR CELL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Male Mice: No Evidence
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3,4-Dihydrocoumarin
119-84-6
Fragrance in cosmetics and detergents. Flavoring agent in foods and beverages. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,75,1200, M: 0,100,1600 MG/KG/10 PER GROUP
International Research & Development Corp.

Levels of Evidence