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Target Organs and Levels of Evidence for TR-424

Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
o-Benzyl-p-chlorophenol
120-32-1
Germicide in disinfectant solutions and soap. Gavage
0,30,480 MG/KG/10 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
o-Benzyl-p-chlorophenol
120-32-1
12/01/1992Germicide in disinfectant solutions and soap. Gavage
MR: 0,30,60,120, FR: 0,60,120,240, M: 0,120,240,480 MG/KG/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • PARATHYROID GLAND: HYPERPLASIA
  • BONE: CRANIAL FIBROUS OSTEODYSTROPHY; FEMUR FIBROUS OSTEODYSTROPHY
  • GLANDULAR STOMACH: MINERALIZATION
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA 0/50 0/50 1/51 1/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50
Non-Neoplastic Lesions
  • KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY
  • BONE: FIBROUS OSTEODYSTROPHY
  • GLANDULAR STOMACH: MINERALIZATION
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED INCIDENCE AND SEVERITY OF NEPHROPATHY
  • BONE: FIBROUS OSTEODYSTROPHY
  • GLANDULAR STOMACH: MINERALIZATION