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Target Organs and Levels of Evidence for TR-427

Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CASRN 8024-37-1) (Major Component 79% Curcumin, CASRN 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Turmeric, oleoresin (curcumin)
8024-37-1
06/23/1992Condiment. Color for ointments. Dosed-Feed
R & M: 0, .2, 1.0, AND 5.0%
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: ULCER; HYPERPLASIA; HYPERKERATOSIS
  • INTESTINES: ULCER; HYPERPLASIA; INFLAMMATION
  • LYMPH NODE: (MESENTERIC) SINUS ECTASIA
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: ADENOMA 5/50 12/48 15/47 16/49 OR CARCINOMA 1/50 4/48 0/47 0/49 COMBINED 6/50 16/48 15/47 16/49
Non-Neoplastic Lesions
  • INTESTINES: ULCER; HYPERPLASIA; INFLAMMATION
  • LYMPH NODE: (MESENTERIC) SINUS ECTASIA
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 25/50 28/50 35/50 30/50 OR CARCINOMA 12/50 18/50 16/50 18/50 COMBINED 30/50 38/50 41/50 37/50
  • Intestines: CARCINOMA 0/50 3/50 3/50 0/50
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 7/50 8/50 19/51 14/50 OR CARCINOMA 7/50 5/50 10/51 6/50 COMBINED 13/50 12/50 25/51 19/50
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA