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Target Organs and Levels of Evidence for TR-432

Toxicology and Carcinogenesis Studies of Barium Chloride Dihydrate (CASRN 10326-27-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Barium chloride dihydrate
10326-27-9
Chemical reagent. Boiler compounds. Pigments and textile dyeing. As a pesticide, and in medicine as a cardiac stimulant.Dosed-Water
0,125,4000 PPM/10 PER GROUP
SRI International

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Barium chloride dihydrate
10326-27-9
06/22/1993Chemical reagent. Boiler compounds. Pigments and textile dyeing. As a pesticide, and in medicine as a cardiac stimulant.Dosed-Water
0,500,1200,2500 PPM
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 35/50 25/50 26/50 15/50
  • ADRENAL GLAND: PHEOCHROMOCYTOMA 11/49 9/50 10/49 6/50 MALIGNANT PHEOCHROMOCYTOMA 2/49 2/50 2/49 0/50 COMBINED 13/49 11/50 12/49 6/50
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY
Other Considerations
  • LIVER: ADENOMA 24/51 20/50 15/48 8/50
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: NEPHROPATHY