National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10975

Target Organs and Levels of Evidence for TR-435

Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4,4-Thiobis(6-tert-butyl-m-cresol)
96-69-5
06/22/1993Antioxidant for synthetic & natural rubber & latexes, stabilizer for polyethylene and polyolefin food packaging (HSDB 1990).Dosed-Feed
R: 0,.05,.1,.25, M: 0,.025,.05,.1 %
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; MIXED CELL FOCI
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; FATTY CHANGE; MIXED CELL FOCI
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA, ADENOMA, OR CARCINOMA COMBINED 32/50 24/50 11/50 16/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • LIVER: FATTY CHANGE 19/50 17/50 5/50 6/50; CLEAR CELL FOCI 6/50 5/50 2/50 0/50; ADENOMA OR CARCINOMA COMBINED 25/50 30/50 27/50 16/50
Female Mice: No Evidence


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