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Target Organs and Levels of Evidence for TR-437

Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Hexachlorocyclopentadiene
77-47-4
06/22/1993Chemical used in the manufacture of flame retardants, resins, and chlorinated cyclodiene pesticides.Inhalation
R:0,.01,.05,.2PPM M:0,.01,.05,.2,.5PPM/50 PER GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
  • NASAL CAVITY: PIGMENTATION
  • TRACHEA: PIGMENTATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LARYNX: SQUAMOUS METAPLASIA
  • LUNG: BRONCHIOLE PIGMENTATION; PERIBRONCHIOLAR PIGMENTATION
  • NASAL CAVITY: PIGMENTATION
  • TRACHEA: PIGMENTATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: MUCOSAL PIGMENTATION
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
  • TRACHEA: MUCOSAL PIGMENTATION
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: MUCOSAL PIGMENTATION
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; MUCOSAL PIGMENTATION
  • TRACHEA: MUCOSAL PIGMENTATION