National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8660

Target Organs and Levels of Evidence for TR-441

Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG)
INIT/PROM
06/21/1994Tumor initiator and promoterTopical Application
DMBA/ACETONE(25,2.5,.25UG),DMBA 2.5,TPA 5 UG,BPO 20MG,DMBA/TPA(.25,2.5,25/5UG),DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO(100,500,1000UG/20MG),MNNG/TPA(1000,1000UG/5UG)
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG)
INIT/PROM
06/21/1994Tumor initiator and promoterTopical Application
DMBA/ACETONE(25,2.5,.25UG):DMBA 2.5:TPA 1UG:BPO 20MG:DMBA/TPA(.25,2.5,25/1UG):DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG):MNNG 100UG:TPA 5UG:BPO 20MG:MNNG/BPO(100,500,1000 UG/20MG)
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG)
INIT/PROM
06/21/1994Tumor initiator and promoterTopical Application
DMBA/ACETONE(50,25,2.5UG),DMBA 2.5,TPA 5UG,BPO 20MG,DMBA/TPA(2.5,25,50UG/5UG),DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO(100,500,1000UG/20MG),MNNG/TPA(100,1000UG/5UG)
Battelle Columbus Laboratory

Levels of Evidence



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