National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8662

Target Organs and Levels of Evidence for TR-442

Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Nitrobenzoic acid
62-23-7
06/22/1993Produced in large volumes for organic synthesis and as an intermediate in the manufacture of pesticides, dyes, and industrial solvents.Dosed-Feed
0, 1250, 2500, OR 5000 PPM /60 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA 29/50 35/50 26/50 2/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: ADENOMA 4/50 12/49 10/49 12/50 OR CARCINOMA 1/50 2/49 5/49 4/50 COMBINED 4/50 14/49 15/49 15/50
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA 17/50 11/50 3/50 0/50
Male Mice: No Evidence
Female Mice: No Evidence


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Nitrobenzoic acid
62-23-7
Produced in large volumes for organic synthesis and as an intermediate in the manufacture of pesticides, dyes, and industrial solvents.Dosed-Feed
R: 0,.062,1.0, M: 0,.125,2.0 %
BioReliance, Inc

Levels of Evidence



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