National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8676

Target Organs and Levels of Evidence for TR-449

Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Triethanolamine
102-71-6
10/30/1998Intermediate in manufacture surfactants, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils, in making mineral & vegetable oil emulsions, solvent, pharmaceutic aid (alkalizer) (Merck 1989). Is widely used as an ingredient in emulsifiers, thickeners, wetting agents, detergents, and alkalinizing agents in cosmetic products; as a chemical intermediate for anionic and nonionic surfactants and surface active agents in household cleaning agents, textiles, herbicides, pharmaceutical ointments, and other products; as a vulcanization accelerator in the manufacture of rubber; and in many other industrial applications.Topical Application
MR: 0, 32, 63, OR 125; FR: 0, 63, 125, OR 250; MM: 0, 200, 630, OR 2000; FM: 0, 100, 300, OR 1000 MG/KG; 60/GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Kidney Tubular Cell: ADENOMA 0/50 1/50 4/49 2/50, STEP SECTIONS 1/50 2/50 6/49 4/50
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS; INFLAMMATION; ULCER
  • KIDNEY: INCREASED SEVERITY OF HYPERPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS; EPIDERMAL EROSION; INFLAMMATION; ULCER
Male Mice: Inadequate Study
Female Mice: Inadequate Study


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