National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8696

Target Organs and Levels of Evidence for TR-459

Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
t-Butylhydroquinone
1948-33-0
06/20/1995Antioxidant in cosmetic products, skin care preparations, vegetable fats and oils, meat products to prevent rancidity, and as a polymerization inhibitor for various polyunsaturated polyesters. Intermediate.Dosed-Feed
R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYSTS; SUPPURATIVE INFLAMMATION
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 10/60 4/60 4/58 7/60 OR ADENOMA 1/57 0/57 1/56 0/58 COMBINED 11/60 4/60 5/58 7/60
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 43/60 33/60 34/58 27/60 OR ADENOMA 3/60 0/60 1/58 2/60 OR CARCINOMA 8/60 6/60 2/58 4/60 COMBINED 48/60 34/60 34/58 30/60
Male Mice: No Evidence
Female Mice: No Evidence


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