National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8702

Target Organs and Levels of Evidence for TR-462

Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (CASRN 1313-27-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Molybdenum trioxide
1313-27-5
In manufacture of molybdenum metals; corrosion inhibitor; industrial catalyst; chemical analysis reagent; alloying agent in steel; a flame retardant for polyester and polyvinyl chloride resins; agricultural chemical; component of ceramics, enamel & pigments.Inhalation
0,1,100 MG/M3/10 PER GROUP
Hazleton, Vienna

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Molybdenum trioxide
1313-27-5
12/05/1995In manufacture of molybdenum metals; corrosion inhibitor; industrial catalyst; chemical analysis reagent; alloying agent in steel; a flame retardant for polyester and polyvinyl chloride resins; agricultural chemical; component of ceramics, enamel & pigments.Inhalation
R&M: 10, 30, OR 100 MG/M3; 50/SEX/SPECIES/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 0/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 1/50 1/50 COMBINED 0/50 1/50 1/50 4/50
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION, ALVEOLUS
  • NASAL CAVITY: HYALINE DEGENERATION, RESPIRATORY EPITHELIUM
  • LARYNX: EPIGLOTTIS, SQUAMOUS METAPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION, ALVEOLUS
  • NASAL CAVITY: RESPIRATORY EPITHELIUM, HYALINE DEGENERATION; OLFACTORY EPITHELIUM, HYALINE DEGENERATION
  • LARYNX: EPIGLOTTIS, SQUAMOUS METAPLASIA
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 14/50 10/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 16/50 14/49 10/50 COMBINED 11/50 27/50 21/49 18/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL METAPLASIA; INFILTRATION, CELLULAR, HISTIOCYTIC
  • NASAL CAVITY: RESPIRATORY EPITHELIUM, HYALINE DEGENERATION
  • LARYNX: EPIGLOTTIS, SQUAMOUS METAPLASIA, HYPERPLASIA
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/49 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 0/49 6/50 COMBINED 3/50 6/50 8/49 15/49
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL METAPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIUM, HYALINE DEGENERATION; RESPIRATORY EPITHELIUM, HYALINE DEGENERATION
  • LARYNX: EPIGLOTTIS, SQUAMOUS METAPLASIA, HYPERPLASIA


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