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Target Organs and Levels of Evidence for TR-482

Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Furfuryl alcohol
98-00-0
Solvent for ethers and esters. In manufacture of phenolic and furan resins. Chemical intermediate. Wetting agent. Liquid propellant. Flavoring agent, obtained from processing corncobs, coffee beans. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0, 2, 4, 8, 16 OR 32 PPM / (10/S/S)
Battelle Northwest Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Furfuryl alcohol
98-00-0
12/10/1997Solvent for ethers and esters. In manufacture of phenolic and furan resins. Chemical intermediate. Wetting agent. Liquid propellant. Flavoring agent, obtained from processing corncobs, coffee beans. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP)
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50
Non-Neoplastic Lesions
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Nasal Cavity: RESPIRATORY EPITHELIUM ADENOMA 0/49 0/50 0/48 1/49; LATERAL WALL ADENOMA 0/49 0/50 1/48 0/49
  • Kidney Tubular Cell: ADENOMA (SINGLE AND STEP SECTIONS) COMBINED 0/50 1/49 2/49 2/50
Non-Neoplastic Lesions
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50
Non-Neoplastic Lesions
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SUPPURATIVE INFLAMMATION; HYPERPLASIA; SQUAMOUS METAPLASIA; (OLFACTORY EPITHELIUM) ATROPHY, HYALINE DEGENERATION, FIBROSIS, HYPERPLASIA, METAPLASIA
  • EYE: CORNEA DEGENERATION 3/49 1/49 4/49 26/50