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Target Organs and Levels of Evidence for TR-484

Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2-Butoxyethanol (ethylene glycol monobutyl ether)
111-76-2
10/30/1998Solvent for mineral oils, in spray lacquers, varnish removers, and inks; in degreasers in industrial and household cleanersInhalation
R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION
  • LIVER: KUPFFER CELL PIGMENTATION
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Adrenal Gland Medulla: BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 3/50 4/50 1/49 8/49
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION
  • LIVER: KUPFFER CELL PIGMENTATION
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Liver): HEMANGIOSARCOMA 0/50 1/50 2/49 4/49
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 1/50 2/49 2/49
  • Liver: HEPATOCELLULAR CARCINOMA 10/50 11/50 16/49 21/49
Non-Neoplastic Lesions
  • FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION
  • BONE MARROW: HYPERPLASIA
  • LIVER: KUPFFER CELL PIGMENTATION
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 5/50 COMBINED 0/50 1/50 2/50 6/50
Non-Neoplastic Lesions
  • FORESTOMACH: ULCER; EPITHELIAL HYPERPLASIA
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; HEMOSIDERIN PIGMENTATION
  • NASAL CAVITY: OLFACTORY EPITHELIUM; HYALINE DEGENERATION; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION
  • LIVER: KUPFFER CELL PIGMENTATION