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https://ntp.niehs.nih.gov/go/14838

Target Organs and Levels of Evidence for TR-495

Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium nitrite
7632-00-0
05/18/2000Chemical. Intermediate, preservative in food, manufacture azo dyes, vasodilator, antidote for cyanide poisoning (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Water
R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 17/50 12/50 7/50 3/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Other Considerations
  • MONONUCLEAR CELL LEUKEMIA: 15/50 10/50 1/50 1/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • GLANDULAR STOMACH: EPITHELIAL HYPERPLASIA
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 1/50 5/50


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium nitrite
7632-00-0
Chemical. Intermediate, preservative in food, manufacture azo dyes, vasodilator, antidote for cyanide poisoning (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Water
R&M: 375 - 5000 PPM/10 PER GROUP
BioReliance, Inc

Levels of Evidence