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https://ntp.niehs.nih.gov/go/14844

Target Organs and Levels of Evidence for TR-498

Toxicology and Carcinogenesis Studies of p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p-Nitrotoluene
99-99-0
05/03/2001Synthesis of intermediates and explosives, stilbene and fuchsin dyes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R&M: 0, 1250, 2500, OR 5000 PPM; 50/SEX/DOSE
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (SUBCUTANEOUS): FIBROMA 1/50 2/50 7/50 1/50 FIBROMA OR FIBROSARCOMA 1/50 2/50 9/50 1/50
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
  • LIVER: BASOPHILIC FOCUS; CLEAR CELL FOCUS; EOSINOPHILIC FOCUS
  • TESTIS: GERMINAL EPITHELIAL ATROPHY
Other Considerations
  • DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 24/50 12/50 5/50 4/50
  • DECREASED INCIDENCES: (TESTIS: INTERSTITIAL CELL ADENOMA) 49/50 46/50 45/50 34/50
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: ADENOMA OR CARCINOMA 8/50 12/50 20/50 8/49
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR HYALINE DROPLET; TUBULAR PIGMENTATION; MINERALIZATION; ONCOCYTIC TUBULAR HYPERPLASIA
  • SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION
  • LIVER: EOSINOPHILIC FOCUS
Other Considerations
  • DECREASED INCIDENCES: (MONONUCLEAR CELL LEUKEMIA) 13/50 12/50 3/50 1/50
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADEMONA OR CARCINOMA 8/50 14/50 12/50 19/50
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION; ALVEOLAR EPITHELIAL HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: ALVEOLAR EPITHELIAL BRONCHIOLIZATION