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Target Organs and Levels of Evidence for TR-505

Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CASRN 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
05/03/2001Perfumery, flavoring agent, intermediate in vitamin A manufacture, main constituent of oil of lemon, orange. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Microencapsulation in Feed
R: 0 (UNTREATED), 0 (VEHICLE), 1000, 2000, OR 4000 PPM M: 0 (UNTREATED), 0 (VEHICLE), 500, 1000, OR 2000 PPM
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: MALIGNANT LYMPHOMA 3/49 5/50 9/50 12/50