National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19369

Target Organs and Levels of Evidence for TR-524

Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical Application Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
alpha/beta Hydroxy acids (glycolic acid, salicylic acid)
HYDROXGLYSAL
09/27/2005Chemical peels of the skin. As part of the alpha/beta-hydroxy acids initiative. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Topical Application
National Center for Toxicological Research

Levels of Evidence

Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Note
  • SKIN: CARCINOMA IN SITU 0.0 MED SSL 0/18 0/18 0/18 0.3 MED SSL 9/18 4/18 1/18 0.6 MED SSL 13/18 15/18 13/18
  • SKIN: CARCINOMA IN SITU OR SQUAMOUS CELL CARCINOMA 0.0 MED SSL 0/18 0/18 0/18 0.3 MED SSL 10/18 4/18 2/18 0.6 MED SSL 18/18 17/18 17/18
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Note
  • SKIN: CARCINOMA IN SITU 0.0 MED SSL 0/18 0/18 0/18 0.3 MED SSL 8/18 4/18 0/17 0.6 MED SSL 14/18 11/18 11/18
  • SKIN: CARCINOMA IN SITU OR SQUAMOUS CELL CARCINOMA 0.0 MED SSL 0/18 0/18 0/18 0.3 MED SSL 8/18 7/18 2/17 0.6 MED SSL 17/18 17/18 14/18


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.