Target Organs and Levels of Evidence for TR-529

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Target Organs and Levels of Evidence for TR-529

Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Primary Uses	Route/Exposure Levels	Study Laboratory
Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) 35065-27-1	12/09/2004	2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.	Gavage FEMALE RATS ONLY: PCB-153 -- 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE	Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CHOLANGIOMA 0/53 0/54 0/53 0/53 2/53 0/51 2/50
Non-Neoplastic Lesions	LIVER: HEPATOCYTE HYPERTROPHY; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; PIGMENTATION THYROID GLAND: FOLLICULAR CELL HYPERTROPHY OVARY: CHRONIC ACTIVE INFLAMMATION OVIDUCT: CHRONIC ACTIVE INFLAMMATION UTERUS: SUPPURATIVE INFLAMMATION; CHRONIC ACTIVE INFLAMMATION

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