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Target Organs and Levels of Evidence for TR-529

Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl)
35065-27-1
12/09/20042,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.Gavage
FEMALE RATS ONLY: PCB-153 -- 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOMA 0/53 0/54 0/53 0/53 2/53 0/51 2/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; PIGMENTATION
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • OVARY: CHRONIC ACTIVE INFLAMMATION
  • OVIDUCT: CHRONIC ACTIVE INFLAMMATION
  • UTERUS: SUPPURATIVE INFLAMMATION; CHRONIC ACTIVE INFLAMMATION