Target Organs and Levels of Evidence for TR-529
Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
| Chemical (Study Title) CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|---|---|---|---|
| Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) 35065-27-1 | 12/09/2004 | 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors. | Gavage FEMALE RATS ONLY: PCB-153 -- 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE | Battelle Columbus Laboratory |
Levels of Evidence
Female Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|---|
| Neoplastic Lesions |
|
| Non-Neoplastic Lesions |
|
