Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/483

Target Organs and Levels of Evidence for TR-529

Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN		Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl)
35065-27-1		12/09/20042,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.Gavage
FEMALE RATS ONLY: PCB-153 -- 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE		Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOMA 0/53 0/54 0/53 0/53 2/53 0/51 2/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; PIGMENTATION
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • OVARY: CHRONIC ACTIVE INFLAMMATION
  • OVIDUCT: CHRONIC ACTIVE INFLAMMATION
  • UTERUS: SUPPURATIVE INFLAMMATION; CHRONIC ACTIVE INFLAMMATION