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Target Organs and Levels of Evidence for TR-530

Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
TEF evaluation (Binary mixture; PCB 126/PCB 153)
TEFBINARYMIX
12/09/2004Used in the electric industry as dielectric insulating fluids for transformers and capacitors. PCBs were also produced for use in hydraulic fluids, solvents, plastics, and paints. One of 2 mixtures being tested along with 5 dioxin-like compounds to determine if the toxic equivalency factors (TEFs) for these chemicals would be predictive of rodent carcinogenicity.Gavage
FEMALE RATS ONLY: 0; (PCB126) 10, 100, 300, OR 1000 NG/KG; (PCB 153) 10, 100, 300, OR 1000 UG/KG; 50/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51
  • Lung: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52
  • Oral Cavity: SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53
  • Pancreas Acinar Cell: ADENOMA 0/53 1/53 1/52 3/52 1/50 ADENOMA OR CARCINOMA 0/53 1/53 1/52 4 /52 2/50
May Have Been Related
  • Uterus/Cervix: SQUAMOUS CELL CARCINOMA 1/53 1/53 1/53 4/53 0/53
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; DIFFUSE FATTY CHANGE; FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; TOXIC HEPATOPATHY; BILE DUCT CYST; BILE DUCT HYPERPLASIA; NECROSIS; OVAL CELL HYPERPLASIA; PORTAL FIBROSIS; NODULAR HYPERPLASIA, CHOLANGIOFIBROSIS
  • LUNG: SQUAMOUS METAPLASIA; ALVEOLAR EPITHELIUM METAPLASIA; BRONCHIOLAR METAPLASIA
  • ORAL CAVITY: GINGIVAL SQUAMOUS HYPERPLASIA
  • PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY
  • ADRENAL CORTEX: ATROPHY; HYPERPLASIA
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • THYMUS: ATROPHY
  • KIDNEY: SEVERITY OF NEPHROPATHY; PIGMENTATION
  • NASAL CAVITY: RESPIRATORY EPITHELIUM HYPERPLASIA; OLFACTORY EPITHELIUM METAPLASIA
  • FORESTOMACH: SQUAMOUS HYPERPLASIA