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https://ntp.niehs.nih.gov/go/LOE-TR-551

Target Organs and Levels of Evidence for TR-551

NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Isoeugenol
97-54-1
02/27/2008Food flavoring agent; fragrance; in manufacture of vanillin. Found in cloves, tobacco, other plants & flowers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&M: 0, 75, 150, OR 300 MG/KG; 50/SEX/SPECIES/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Thymus: Thymoma, benign or malignant 0/47 0/43 0/49 2/48
  • Mammary Gland: Carcinoma 0/50 0/50 0/50 2/50
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, atrophy, degeneration, respiratory metaplasia
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, atrophy, respiratory metaplasia
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 24/50 35/50 37/50 33/50 carcinoma 8/50 18/50 19/50 18/50 adenoma or carcinoma 28/50 43/50 43/50 43/50
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, atrophy, respiratory metaplasia, degeneration; hyaline droplet accumulation; glands, hyperplasia
  • Grandular stomach: Ulcer
  • Forestomach: Hyperplasia, squamous; inflammation; ulcer
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • All Organs: Histiocytic sarcoma 0/49 1/50 1/50 4/50
Non-Neoplastic Lesions
  • Nasal cavity: Olfactory epithelium, atrophy, respiratory metaplasia, hyaline droplet accumulation; glands, hyperplasia
  • Glandular stomach: Ulcer
  • Forestomach: Hyperplasia, squamous; inflammation