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Target Organs and Levels of Evidence for TR-559

Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
TEF evaluation (PCB 118)
31508-00-6
02/25/2009Polychlorinated biphenyls (PCBs) and their mixtures including 2,3',4,4',5-pentachlorobiphenyl (PCB 118) were produced commercially before 1977 for the electric industry as dielectric insulating fluids for transformers and capacitors. One of 2 dioxin-like being tested to determine if the toxic equivalency factors (TEFs) for these chemicals would be predictive of rodent carcinogenicity.Gavage
50 FEMALE RATS: 0, 100, 220, 460, 1000, 4600 UG/KG AND 4600 UG/KG (STOP EXPOSURE)
Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49
  • Lung: Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50
  • Uterus: Carcinoma 2/52 2/52 1/52 3/52 4/52 3/52 11/50
May Have Been Related
  • Pancreas Acinar Cell: Ademona 0/52 0/52 0/52 2/52 3/52 1/47 0/49 adenoma or carcinoma 0/50 0/52 0/52 2/52 3/52 2/47 0/49
  • Uterus: Squamous cell carcinoma: 0/52 0/52 3/52 1/52 1/52 0/52 1/50
Non-Neoplastic Lesions
  • Liver: Hepatocyte hypertrophy; multinucleated hepatocyte; eosinophilic focus; mixed cell focus; hyperplasia, nodular; inflammation; necrosis; fatty change, diffuse; bile duct hyperplasia; oval cell hyperplasia; bile duct cyst; pigmentation; cholangiofibrosis; toxic hepatopathy
  • Lung: Alveolar epithelium, metaplasia, bronchiolar; squamous metaplasia
  • Adrenal Cortex: Atrophy; cytoplasmic vacuolization
  • Pancreas: Acinus, cytoplasmic vacuolization; artery, inflammation, chronic active
  • Thyroid Gland: Follicular cell, hypertrophy
  • Nasal Cavity: Inflammation; respiratory epithelium, hyperplasia
  • Kidney: Pigmentation