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Target Organs and Levels of Evidence for TR-573

Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies)

Chemical
CASRN		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Styrene-acrylonitrile trimer
SANTRIMER2		 01/26/2011 Chemicals record created for testing of styrene-acrylonitrile drinking water studyDosed-Feed
R: 0, 400, 800, or 1600 ppm; 50/sex/dose		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Spinal nerve roots: nerve fiber degeneration; Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: eosinophilic focus; mixed cell focus
Other Considerations
  • Pituitary gland (par distalis): Adenoma; mononuclear cell leukemia

Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: mixed cell focus; Urinary bladder: transitional epithelium hyperplasia
Other Considerations
  • Pituitary gland (par distalis): Adenoma; mammary gland, fibroadenoma; mononuclear cell leukemia