https://ntp.niehs.nih.gov/go/37127
Target Organs and Levels of Evidence for TR-573
Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies)
Chemical
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
Styrene-acrylonitrile trimer
SANTRIMER2 | 01/26/2011 | Chemicals record created for testing of styrene-acrylonitrile drinking water study | Dosed-Feed
R: 0, 400, 800, or 1600 ppm; 50/sex/dose | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions | - Spinal nerve roots: nerve fiber degeneration; Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: eosinophilic focus; mixed cell focus
|
| Other Considerations | - Pituitary gland (par distalis): Adenoma; mononuclear cell leukemia
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions | - Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: mixed cell focus; Urinary bladder: transitional epithelium hyperplasia
|
| Other Considerations | - Pituitary gland (par distalis): Adenoma; mammary gland, fibroadenoma; mononuclear cell leukemia
|
