Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/37127

Styrene-acrylonitrile trimer: Target Organs and Levels of Evidence for TR-573

Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies)

Chemical
CASRN		 Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Styrene-acrylonitrile trimer
SANTRIMER2		 01/26/2011 Chemicals record created for testing of styrene-acrylonitrile drinking water studyDosed-Feed
R: 0, 400, 800, or 1600 ppm; 50/sex/dose		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Spinal nerve roots: nerve fiber degeneration; Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: eosinophilic focus; mixed cell focus
Other Considerations
  • Pituitary gland (par distalis): Adenoma; mononuclear cell leukemia

Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Sciatic nerve: nerve fiber degeneration; Bone marrow: hyperplasia; granulomatous inflammation; Liver: mixed cell focus; Urinary bladder: transitional epithelium hyperplasia
Other Considerations
  • Pituitary gland (par distalis): Adenoma; mammary gland, fibroadenoma; mononuclear cell leukemia