Toxicology in the 21st Century (Tox21)
Through HTS, the collaboration is testing a collection of more than 10,000 environmental chemicals, drugs, and formulations to broadly characterize and define their chemical reactivity in biochemical- and cell-based assays. Building on the strengths of each partner, Tox21 facilitates the advancement of toxicology to a more predictive science, based on the most relevant and meaningful tools of modern molecular biology and chemistry. The convergence of science, technology, regulatory need, and public opinion has created the opportunity to transform toxicology and risk assessment into more accurate, rapid, and cost-effective sciences. Additionally, Tox21 supports the goals of reduction, refinement, and replacement of animals in toxicity testing (NTP Interagency Center for the Evaluation of Alternative Toxicological Methods Tox21 activities).
Goals of the Tox21 ProgramThe goal of Tox21 is to research, develop, validate, and translate innovative test methods that will better predict how chemicals may affect humans and the environment. Tox21 researchers hope to use the results from these methods to:
- Prioritize substances for further in-depth toxicological evaluation
- Identify mechanisms of action for further investigation (e.g., disease-associated pathways)
- Develop models that better predict how chemicals will affect biological responses (predictive toxicology)
For further information on NTP's Tox21 program, contact:
Richard S. Paules, Ph.D.
Acting Chief, Biomolecular Screening Branch
NIEHS/Division of NTP
P.O. Box 12233,
Research Triangle Park, NC 27709