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Tox21 Fact Sheets and Selected Publications

Tox21 Fact Sheets

Tox21: Chemical testing in the 21st century (729KB)
United States Federal Government Collaboration Toxicology in the 21st Century (Tox21): Testing Thousands of Environmental Chemicals Using Non-Animal Methods

Tox21 Selected Publications

Tox21 logo
2016 to present

Ryan, K. R., Sirenko, O., Parham, F., Hsieh, J.-H., Cromwell, E. F., Tice, R. R., & Behl, M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high- throughput screen for developmental neurotoxicity or neurotoxicity. NeuroToxicology. 
doi: http://dx.doi.org/10.1016/j.neuro.2016.02.003

2011–2015

Hsieh, J. H., Sedykh, A., Huang, R., Xia, M., & Tice, R. R. (2015). A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays. J Biomol Screen, 20(7), 887-897.
doi: http://dx.doi.org/10.1177/1087057115581317

Chen, S., Hsieh, J. H., Huang, R., Sakamuru, S., Hsin, L. Y., Xia, M., ... ,Tice, R. R. (2015). Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library. Toxicol Sci, 147(2), 446-457.
doi: http://dx.doi.org/10.1093/toxsci/kfv141

Behl, M., Hsieh, J.-H., Shafer, T. J., Mundy, W. R., Rice, J. R., Boyd, W. A., ... Tice, R. R. (2015). Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicology and Teratology, 52, Part B, 181-193.
doi: http://dx.doi.org/10.1016/j.ntt.2015.09.003

Adler, M., Ramm, S., Hafner, M., Muhlich, J. L., Gottwald, E. M., Weber, E., ... ,Vaidya, V. S. (2015). A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol.
doi: http://dx.doi.org/10.1681/asn.2015010060

Attene-Ramos M. S., Huang, R., Michael, S., Witt, K. L., Richard, A., Tice, R. R., … Xia, M. (2015). Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect, 123(1), 49-56.
http://dx.doi.org/10.1289/ehp.1408642

Huang, R., Sakamuru, S., Martin, M. T., Reif, D. M., Judson, R. S., Houck, K. A., . . . Xia, M. (2014). Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Sci Rep, 4, 5664.
doi: http://dx.doi.org/10.1038/srep05664

Tice, R. R., Austin, C. P., Kavlock, R. J., & Bucher, J. R. (2013). Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect, 121(7), 756-765. 
doi: http://dx.doi.org/10.1289/ehp.1205784

Attene-Ramos, M. S., Miller, N., Huang, R., Michael, S., Itkin, M., Kavlock, R. J., ... ,Xia, M. (2013). The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discov Today, 18(15-16), 716-723. 
doi: http://dx.doi.org/10.1016/j.drudis.2013.05.015

Huang, R., Xia, M., Cho, M. H., Sakamuru, S., Shinn, P., Houck, K. A., … Austin, C. P. (2011). Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect, 119(8), 1142-1148.
doi: http://dx.doi.org/10.1289/ehp.1002952

 

2005–2010

Xia, M., Huang, R., Sun, Y., Semenza, G. L., Aldred, S. F., Witt, K. L., ... ,Austin, C. P. (2009). Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci, 112(1), 153-163. 
doi: http://dx.doi.org/10.1093/toxsci/kfp123

Parham, F., Austin, C., Southall, N., Huang, R., Tice, R., & Portier, C. (2009). Dose-response modeling of high-throughput screening data. J Biomol Screen, 14(10), 1216-1227
doi: http://dx.doi.org/10.1177/1087057109349355

Kavlock, R. J., Austin, C. P., & Tice, R. R. (2009). Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal, 29(4), 485-487; discussion 492-487.
doi: http://dx.doi.org/10.1111/j.1539-6924.2008.01168.x

Huang, R., Southall, N., Xia, M., Cho, M. H., Jadhav, A., Nguyen, D. T., ... ,,Austin, C. P. (2009). Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicol Sci, 112(2), 385-393.
doi: http://dx.doi.org/10.1093/toxsci/kfp231

Xia, M., Huang, R., Witt, K. L., Southall, N., Fostel, J., Cho, M.-H., ... ,Austin, C. P. (2008). Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening. Environmental Health Perspectives, 116(3), 284-291.
doi: http://dx.doi.org/10.1289/ehp.10727

Huang, R., Southall, N., Cho, M. H., Xia, M., Inglese, J., & Austin, C. P. (2008). Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem Res Toxicol, 21(3), 659-667.
doi: http://dx.doi.org/10.1021/tx700365e

Collins, F. S., Gray, G. M., & Bucher, J. R. (2008). Toxicology. Transforming environmental health protection. Science, 319(5865), 906-907. 
doi: http://dx.doi.org/10.1126/science.1154619