https://ntp.niehs.nih.gov/go/niceatm-training

Integrated Chemical Environment Training 2024

May 22, 2024 – 1:00-4:00 p.m. EDT
In-person only: Natcher Conference Center, National Institutes of Health, Bethesda, MD

Register to attend the training - register by Friday, May 17

NICEATM is hosting a training session focused on the Integrated Chemical Environment (ICE), including opportunities to learn about its latest updates. ICE is a globally used platform that provides user-friendly access to high-quality data and tools to support the evaluation of chemical toxicity. This training will cover a general overview of ICE, its data and curated chemical lists, and live demonstrations of different ICE tools, including:

  • Search Tool – Explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest.
  • Chemical Quest Tool - Identify structurally similar chemicals.
  • Chemical Characterization Tool - Compare chemical properties and chemical use categories.
  • Curve Surfer Tool - Explore concentration-response curves and bioactivity with curated high-throughput screening data.
  • PBPK Tool - Predict tissue-specific chemical concentration profiles following a dosing event.
  • IVIVE Tool - Estimate the in vivo equivalent administered dose from in vitro data.

It is optional but recommended for attendees that wish to participate in live demonstrations to bring their laptops to the training.

Agenda

Time (EDT) Topic
1:00-1:50 p.m. Introduction to ICE
Data Sets and Curated Chemical Lists in ICE
Search Tool: explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest 
1:50-2:00 p.m. Break
2:00-2:50 p.m. Chemical Quest Tool: identify structurally similar chemicals
Chemical Characterization Tool: compare chemical properties and chemical use categories
Curve Surfer Tool: explore concentration-response curves and bioactivity with curated high-throughput screening data
2:50-3:00 p.m. Break
3:00-3:50 p.m. PBPK Tool: predict tissue-specific chemical concentration profiles following a dosing event 
IVIVE Tool: estimate the in vivo equivalent administered dose from in vitro data 
Q&A