On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/iccvam-dev

Developmental Toxicity

Developmental toxicity tests evaluate the extent to which substances can interfere with normal development and cause adverse effects in the offspring. Testing for a chemical's potential to cause developmental toxicity is required by multiple regulatory agencies and uses large numbers of animals. NICEATM supports efforts to develop, validate, and implement alternatives to animal testing to identify potential developmental toxicants.

Descriptions

Collage representing data and computer servers

Curation of Developmental Toxicity Reference Data

NICEATM is exploring approaches to standardizing and automating collection of developmental toxicity data. More
Set of test tubes filled with blue liquid

Non-animal Methods & Strategies

Advancing alternatives to animal testing for developmental toxicity is a top concern of NICEATM. Researchers can submit data to support this effort. Go
Illustration includes a fish, fish eggs, a 96-well plate, and a molecule

Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT)

NTP established the SEAZIT program to enable the adoption of zebrafish for toxicological screening. Find out about SEAZIT activities. Go