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Developmental Toxicity

Developmental toxicity tests evaluate the extent to which substances can interfere with normal development and cause adverse effects in the offspring. Testing for a chemical's potential to cause developmental toxicity is required by multiple regulatory agencies and uses large numbers of animals. NICEATM supports efforts to develop, validate, and implement alternatives to animal testing to identify potential developmental toxicants.


Collage representing data and computer servers

Curation of Developmental Toxicity Reference Data

NICEATM is exploring approaches to standardizing and automating collection of developmental toxicity data. More
Set of test tubes filled with blue liquid

Non-animal Methods & Strategies

Advancing alternatives to animal testing for developmental toxicity is a top concern of NICEATM. Researchers can submit data to support this effort. Go
Illustration of brown fish

Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT)

NTP established the SEAZIT program to enable the adoption of zebrafish for toxicological screening. Find out about SEAZIT activities. Go
Frog embryos

FETAX Evaluation

The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) was considered for use as a developmental toxicity screen. Read more about this evaluation. Go