TDMS Study 05135-06 Pathology Tables
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 X X |
Deformity | |
Eosinophilic Focus | X |
Vacuolization Cytoplasmic | 1 2 2 1 2 1 2 2 2 2 2 3 2 1 1 |
|__________________________________________________________________________|
Mesentery | + |
Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 1 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pericardium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 1 1 1 1 |
Hypertrophy, Focal | 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + M + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Intermedia, Hyperplasia | 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia | 2 |
Inguinal, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + + + + + + + + M M M + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + M M + M M + + + + M + + M + + M + + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M M M + + + M M + M M + + + M + + M M M +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Pigmentation, Melanin | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Olfactory Epithelium, | |
Degeneration | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Fibrosis | 1 |
Bilateral, Hydronephrosis | |
Bilateral, Metaplasia, Osseous | |
Bilateral, Pelvis, Inflammation, | |
Suppurative | |
Bilateral, Renal Tubule, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Dilatation | 2 |
Inflammation, Suppurative | 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Basophilic Focus | | 3 4.0|
Deformity | X | 1 |
Eosinophilic Focus | | 1 |
Vacuolization Cytoplasmic | 1 2 2 2 2 2 1 | 22 1.7|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Focal Cellular Change | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
Inflammation, Suppurative | | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
Pericardium, Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 1 | 6 1.0|
Hypertrophy, Focal | 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 2 | 9 1.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + + + + + | 34 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M M + + + + | 38 |
Pars Distalis, Cyst | | 2 |
Pars Intermedia, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 40 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + M + + + + + + | 38 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Hyperplasia | | 1 2.0|
Inguinal, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + M + + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M M + M M M + + | 24 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M + M M + + M + + M + M | 19 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Hematopoietic Cell Proliferation | | 2 2.0|
Pigmentation, Melanin | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
Prepuce, Inflammation, Chronic | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
Degeneration | 1 1 | 4 1.0|
Meninges, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Congestion | 1 | 3 1.7|
Hemorrhage | 2 1 2 | 3 1.7|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Olfactory Epithelium, | | |
Degeneration | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Bilateral, Fibrosis | 2 | 2 1.5|
Bilateral, Hydronephrosis | 2 2 | 2 2.0|
Bilateral, Metaplasia, Osseous | 1 | 1 1.0|
Bilateral, Pelvis, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Bilateral, Renal Tubule, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Calculus Micro Observation Only | X | 1 |
Dilatation | | 1 2.0|
Inflammation, Suppurative | 2 | 2 1.5|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + |
|__________________________________________________________________________|
Gallbladder | + A |
|__________________________________________________________________________|
Intestine Large, Colon | + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + A |
|__________________________________________________________________________|
Intestine Small, Ileum | + A |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Infarct | 4 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Mesentery | + + |
Necrosis | 2 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Inflammation, Chronic | 1 1 |
Duct, Cyst | X |
|__________________________________________________________________________|
Pharynx | + + |
|__________________________________________________________________________|
Salivary Glands | + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperplasia | 2 |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 1 |
|__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + |
|__________________________________________________________________________|
Adrenal Medulla | + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + |
|__________________________________________________________________________|
Pituitary Gland | + + |
|__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + |
Inflammation | 2 |
|__________________________________________________________________________|
Preputial Gland | + + |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 1 |
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Necrosis | 2 |
|__________________________________________________________________________|
Prostate | + + |
|__________________________________________________________________________|
Seminal Vesicle | + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + |
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hyperplasia | 2 |
Necrosis | 2 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
|__________________________________________________________________________|
Spleen | + + + + + |
Accessory Spleen | X |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 |
Pigmentation, Melanin | 2 2 |
|__________________________________________________________________________|
Thymus | + + |
Necrosis | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Skin | + + + + |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 1 |
Prepuce, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Olfactory Epithelium, | |
Degeneration | 2 1 |
|__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + |
Bilateral, Hydronephrosis | 1 |
Bilateral, Pelvis, Inflammation, | |
Suppurative | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + |
Calculus Micro Observation Only | X |
Dilatation | 3 2 |
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Basophilic Focus | | 1 |
Infarct | | 1 4.0|
Vacuolization Cytoplasmic | 2 1 1 1 1 2 1 | 25 1.2|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Necrosis | | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Focal Cellular Change | 2 | 1 2.0|
Inflammation, Chronic | | 2 1.0|
Duct, Cyst | | 1 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 | 9 1.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 12 |
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 13 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 4 | 3 2.3|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + M M | 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 13 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + M + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 15 |
Accessory Spleen | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation, Melanin | 1 | 3 1.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 12 |
Necrosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 14 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 2 1.5|
Prepuce, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
Degeneration | 1 1 1 1 | 20 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Olfactory Epithelium, | | |
Degeneration | | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 13 |
Bilateral, Hydronephrosis | | 1 1.0|
Bilateral, Pelvis, Inflammation, | | |
Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 15 |
Calculus Micro Observation Only | | 1 |
Dilatation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | A |
|__________________________________________________________________________|
Gallbladder | A |
|__________________________________________________________________________|
Intestine Large, Colon | A |
|__________________________________________________________________________|
Intestine Large, Rectum | A |
|__________________________________________________________________________|
Intestine Large, Cecum | A |
|__________________________________________________________________________|
Intestine Small, Duodenum | A |
|__________________________________________________________________________|
Intestine Small, Jejunum | A |
|__________________________________________________________________________|
Intestine Small, Ileum | A |
|__________________________________________________________________________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Mixed Cell Focus | X |
Necrosis | 1|
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1|
|__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + |
|__________________________________________________________________________|
Salivary Glands | A |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
Tooth | + |
Deformity | |
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | A |
|__________________________________________________________________________|
Heart | A |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | A |
|__________________________________________________________________________|
Adrenal Medulla | A |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 2 2 2 2 1 |
|__________________________________________________________________________|
Parathyroid Gland | A |
|__________________________________________________________________________|
Pituitary Gland | A |
Pars Distalis, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | A |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | A |
|__________________________________________________________________________|
Preputial Gland | A |
|__________________________________________________________________________|
Prostate | A |
|__________________________________________________________________________|
Seminal Vesicle | A |
|__________________________________________________________________________|
Testes | + + + + A + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | A |
|__________________________________________________________________________|
Lymph Node, Bronchial | A |
|__________________________________________________________________________|
Lymph Node, Mandibular | A |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A |
|__________________________________________________________________________|
Lymph Node, Mediastinal | A |
|__________________________________________________________________________|
Spleen | A |
|__________________________________________________________________________|
Thymus | A |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | A |
|__________________________________________________________________________|
Skin | A |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | A + |
Osteopetrosis | 1 |
|__________________________________________________________________________|
Skeletal Muscle | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | A |
Cyst Epithelial Inclusion | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + A + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Meninges, Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | A |
|__________________________________________________________________________|
Lung | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
|__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +|
Turbinate, Inflammation | 1 |
Turbinate, Olfactory Epithelium, | |
Degeneration | 1 1 1 1 |
|__________________________________________________________________________|
Trachea | A |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A |
|__________________________________________________________________________|
Urinary Bladder | A |
__________________________________________|__________________________________________________________________________
Page 26
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 39 |
Basophilic Focus | 3 | 2 3.0|
Mixed Cell Focus | | 1 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 27 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 39 |
Infiltration Cellular, Mast Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Tongue | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Deformity | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | M + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 39 |
Hyperplasia | 2 1 1 | 12 1.6|
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + M + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + | 10 |
Pars Distalis, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Preputial Gland | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 39 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + M M + + | 7 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Osteopetrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 39 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 11 |
Cyst Epithelial Inclusion | X | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
Degeneration | 1 1 1 | 19 1.0|
Meninges, Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 39 |
Hemorrhage | | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 39 |
Turbinate, Inflammation | | 1 1.0|
Turbinate, Olfactory Epithelium, | | |
Degeneration | 1 | 5 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + | 39 |
Hyperplasia | 3 1 1 | 3 1.7|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + |
|__________________________________________________________________________|
Gallbladder | + A |
Inflammation, Suppurative | |
|__________________________________________________________________________|
Intestine Large, Colon | + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + |
Parasite | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | X |
Clear Cell Focus | 1 2 |
Eosinophilic Focus | 3 2 2 2 1 |
Mixed Cell Focus | 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + |
Angiectasis | 1 |
Necrosis | 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 1 1 |
|__________________________________________________________________________|
Pharynx | + + |
|__________________________________________________________________________|
Salivary Glands | + + |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 1 2 2 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 X |
Inflammation, Suppurative | 1 |
Pigmentation, Hemosiderin | 2 |
Ulcer | 2 |
|__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + |
|__________________________________________________________________________|
Adrenal Medulla | + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 3 2 1 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + |
|__________________________________________________________________________|
Pituitary Gland | + + |
|__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Epididymis | + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + |
Angiectasis | 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Prostate | + + |
Inflammation, Suppurative | 2 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + |
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + M + |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
|__________________________________________________________________________|
Spleen | + + |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation, Melanin | |
|__________________________________________________________________________|
Thymus | + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Skin | + + |
Prepuce, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + |
Hemorrhage | 2 |
Necrosis | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + M + + + + + + + + + + + + + + +|
Sciatic, Degeneration | 1 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 2 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Inflammation | 1 |
Turbinate, Olfactory Epithelium, | |
Degeneration | 1 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Trachea | + + |
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + |
Bilateral, Hydronephrosis | 4 |
Bilateral, Cortex, Pelvis, | |
Inflammation, Suppurative | 3 |
Bilateral, Pelvis, Inflammation, | |
Suppurative | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + |
Dilatation | 2 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________
Page 36
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + | 12 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 14 |
Parasite | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Angiectasis | | 2 2.0|
Basophilic Focus | 2 4 X | 4 3.0|
Clear Cell Focus | | 2 1.5|
Eosinophilic Focus | 3 | 6 2.2|
Mixed Cell Focus | | 1 1.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 2 1 1 2 | 20 1.2|
|__________________________________________________________________________|____________|
Mesentery | | 2 |
Angiectasis | | 1 1.0|
Necrosis | | 2 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Focal Cellular Change | 1 | 5 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Epithelium, Hyperplasia | 2 1 3 3 2 4 4 2 2 4 1 | 16 2.2|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | | 3 1.0|
Inflammation, Suppurative | | 1 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 | 12 1.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 16 |
Angiectasis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + | 13 |
Inflammation, Suppurative | | 2 2.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 13 |
Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 13 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + M + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + | 13 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mediastinal | M + M + + M + + + M + | 9 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 13 |
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation, Melanin | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 13 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 14 |
Prepuce, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 13 |
Hemorrhage | 1 | 2 1.5|
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 39 |
Sciatic, Degeneration | | 1 1.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
Degeneration | 1 1 1 1 | 28 1.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | | 1 3.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Inflammation | | 1 1.0|
Turbinate, Olfactory Epithelium, | | |
Degeneration | 1 1 | 12 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 14 |
Bilateral, Hydronephrosis | | 1 4.0|
Bilateral, Cortex, Pelvis, | | |
Inflammation, Suppurative | | 1 3.0|
Bilateral, Pelvis, Inflammation, | | |
Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Dilatation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + A + + A + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + A + + A + + +|
Serosa, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 2 X |
Eosinophilic Focus | 3 4 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 4 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + |
Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Epithelium, Hyperplasia | 3 4 4 4 3 1 2 2 1 2 4 3 4 3|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + M + + + + + + + + + + A + + +|
Hyperplasia | 1 2 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + M + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 1 1 1 1 |
Hypertrophy, Focal | 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + M M M + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 4 |
Inflammation, Suppurative | 1 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4|
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + M + + + + + M + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + M + + + M M + M + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + + M M M + M + + + M + + + M M + + M M|
Hyperplasia | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Pigmentation, Melanin | 1 |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | 3 |
Prepuce, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + M + + A + + +|
Sciatic, Degeneration | 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + A + + +|
Degeneration | 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + A + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Olfactory Epithelium, | |
Degeneration | 1 1 1 2 1 1 2 1 1 1 1 2 1 1 2 1|
Turbinate, Olfactory Epithelium, | |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Hydronephrosis | 2 |
Bilateral, Metaplasia, Osseous | |
Bilateral, Renal Tubule, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 47
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 37 |
Inflammation, Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 37 |
Serosa, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | 4 | 5 2.5|
Eosinophilic Focus | 4 4 | 5 3.4|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia, Focal | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | 1 | 2 1.5|
Vacuolization Cytoplasmic | 1 1 2 1 1 2 1 1 1 1 | 24 1.1|
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
Necrosis | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Focal Cellular Change | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Angiectasis | 1 | 2 1.5|
Epithelium, Hyperplasia | 3 1 2 2 4 | 19 2.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 38 |
Hyperplasia | | 2 1.5|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 39 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 1 1 1 1 | 8 1.0|
Hypertrophy, Focal | 1 1 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 1 1 1 2 1 3 1 | 16 1.3|
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + M + + + M + + + + | 32 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 39 |
Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 39 |
Atrophy | | 1 4.0|
Inflammation, Suppurative | | 1 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + + + + + + | 39 |
Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
Angiectasis | | 1 4.0|
Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + M | 33 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 39 |
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M + + + + + + + M | 20 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Hematopoietic Cell Proliferation | 4 | 2 3.5|
Pigmentation, Melanin | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 39 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage | | 1 3.0|
Prepuce, Inflammation, Chronic | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 38 |
Sciatic, Degeneration | | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Hemorrhage | 1 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Olfactory Epithelium, | | |
Degeneration | 1 1 2 2 1 2 1 1 1 2 | 26 1.3|
Turbinate, Olfactory Epithelium, | | |
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 3 | 3 1.7|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + + + + + + + + + + + + + | 40 |
Bilateral, Hydronephrosis | | 1 2.0|
Bilateral, Metaplasia, Osseous | 1 | 1 1.0|
Bilateral, Renal Tubule, Hyperplasia | | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + A + + + + + M + M M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + + + + + + + +|
Parasite | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + + + + + + + +|
Parasite | X |
|__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | 4 4 4 2 |
Clear Cell Focus | |
Eosinophilic Focus | 2 X 2 |
Hematopoietic Cell Proliferation | 1 |
Mixed Cell Focus | 2 2 |
Necrosis | 1 1 |
Vacuolization Cytoplasmic | 2 2 1 1 1 1 2 2 2 2 2|
Bile Duct, Hyperplasia | 2 |
|__________________________________________________________________________|
Mesentery | + |
Necrosis | 4 |
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | 1 2 1 1 1 |
Inflammation, Chronic | |
Duct, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 2 2 4 4 3 2 2 4 4|
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1|
Inflammation, Suppurative | 1 2 |
Necrosis | 1 2 |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 1 2 1 1 1 |
Hypertrophy, Focal | 1 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + M + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation | 1 |
|__________________________________________________________________________|
Penis | + + |
|__________________________________________________________________________|
Preputial Gland | + A + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis | |
Atrophy | 4 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 2 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + M + + + + + + + + + + + + + M + + + M +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + M + + + M + + + M M + + M M + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mediastinal | M M M M M M + M + M + + M + M + + + + + + M + M +|
|__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 2 |
|__________________________________________________________________________|
Thymus | + M + + + M + + + M + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Prepuce, Inflammation, Chronic | 4 |
Sebaceous Gland, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + A + + + + + + + + + + + + + + + + + + + + + + +|
Sciatic, Degeneration | 1 1 1 2 1 |
|__________________________________________________________________________|
Spinal Cord | + A + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Meninges, Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Inflammation | 1 |
|__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 2 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 |
Turbinate, Inflammation, Suppurative | 2 |
Turbinate, Olfactory Epithelium, | |
Degeneration | 2 2 2 1 2 1 1 2 2 2 2 2 3 1 2 2 2 2 3 2 1 2 1 2|
Turbinate, Olfactory Epithelium, | |
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 1 2 2 1 1 1 1 2|
|__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Harderian Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Fibrosis, Focal | 2 |
Bilateral, Fibrosis | 2 |
Bilateral, Hydronephrosis | 2 |
Bilateral, Nephropathy | 2 |
|__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
__________________________________________|__________________________________________________________________________
Page 58
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + A | 33 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A | 36 |
Parasite | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A | 36 |
Parasite | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + A + + + + + | 38 |
Angiectasis | | 2 1.5|
Basophilic Focus | | 4 3.5|
Clear Cell Focus | 1 | 1 1.0|
Eosinophilic Focus | | 3 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Mixed Cell Focus | 2 | 3 2.0|
Necrosis | | 2 1.0|
Vacuolization Cytoplasmic | 1 3 3 | 14 1.8|
Bile Duct, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 2 |
Necrosis | 2 | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Angiectasis | 1 | 1 1.0|
Focal Cellular Change | 1 | 6 1.2|
Inflammation, Chronic | 2 | 1 2.0|
Duct, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + | 38 |
Epithelium, Hyperplasia | 2 1 3 1 4 | 15 2.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + | 37 |
Hyperplasia | 1 | 4 1.5|
Inflammation, Suppurative | | 2 1.5|
Necrosis | | 2 1.5|
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + | 38 |
Hyperplasia, Focal | 1 | 1 1.0|
Hyperplasia | 1 | 6 1.2|
Hypertrophy, Focal | 1 | 4 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + A + + + + + | 38 |
Angiectasis | 1 | 1 1.0|
Hyperplasia | 1 2 1 1 2 | 13 1.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + M | 34 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + A + + M + M | 35 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + | 38 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + A + + + + + | 39 |
Hyperplasia | | 1 4.0|
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Penis | A | 2 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + A + + + + + | 37 |
Angiectasis | 1 | 1 1.0|
Atrophy | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + | 37 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + A + + + + + | 39 |
Atrophy | 3 3 1 | 8 2.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + | 38 |
Hyperplasia | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + M M + + + + | 32 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M + + + + A M + M + M | 23 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + M + | 37 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + + M A + M M + + | 22 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + | 38 |
Hematopoietic Cell Proliferation | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + + + + + | 36 |
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + A + + + + + | 39 |
Inflammation, Suppurative | | 1 1.0|
Prepuce, Inflammation, Chronic | 4 | 2 4.0|
Sebaceous Gland, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + A + + + + + | 38 |
Atrophy | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + A + + + + + | 38 |
Sciatic, Degeneration | | 5 1.2|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + A + + + + + | 38 |
Degeneration | 1 1 1 1 1 1 1 1 | 23 1.0|
Meninges, Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + | 38 |
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + A + + + + + | 38 |
Congestion | 2 | 2 2.5|
Hemorrhage | | 2 1.5|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 4 4 4 1 2 | 7 2.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + | 38 |
Inflammation | | 2 2.0|
Turbinate, Inflammation, Suppurative | | 1 2.0|
Turbinate, Olfactory Epithelium, | | |
Degeneration | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 | 38 1.9|
Turbinate, Olfactory Epithelium, | | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.2|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05135-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:31:26
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + A + + + + + | 38 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + | 38 |
Bilateral, Fibrosis, Focal | | 1 2.0|
Bilateral, Fibrosis | | 1 2.0|
Bilateral, Hydronephrosis | | 1 2.0|
Bilateral, Nephropathy | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + | 38 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
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---------- END OF REPORT ----------
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