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Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Final Documents
September 24–25, 2015

Workshop report (Toxicology in Vitro)

Alternative Approaches to Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing Presentations
September 24–25, 2015

Session 1: The Regulatory Landscape: When Is Acute Toxicity Data Required and How Is It Used?

U.S. Consumer Product Safety Commission
Joanna Matheson, Ph.D., Directorate for Health Sciences, U.S. Consumer Product Safety Commission

Acute Toxicity Testing: Office of Pesticide Programs
Elissa Reaves, Ph.D., Office of Pesticide Programs, U.S. Environmental Protection Agency (EPA)

Requirements and Evaluation of Toxicity Testing in the TSCA New Chemicals Program
Louis Scarano, Ph.D., Office of Pollution Prevention and Toxics, EPA

Session 2: State of the Science for Acute Toxicity Testing Methods

Alternative Methods for Acute Systemic Toxicity Testing
Rabea Graepel, Ph.D., Systems Toxicity Unit, European Union Reference Laboratory for Alternatives to Animal Testing

From QSAR to Big Data: Developing Mechanism-Driven Predictive Models for Animal Toxicity
Hao Zhu, Ph.D., Department of Chemistry, Rutgers University-Camden

Biokinetic Considerations in the Use of In Vitro Systems for Estimating Acute (Systemic) Toxicity
Bas Blaauboer, Institute for Risk Assessment Sciences, Utrecht University

NRC Report: Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense
David Dorman, D.V.M., Ph.D., Department of Molecular Biosciences, North Carolina State University

Session 3: Case Studies

Vision for Animal-free Pesticide Formulation Assessments
Sean Gehen, Ph.D., Dow AgroSciences LLC

Predicting Acute Toxicity Hazard in the Absence of Experimental Data: Case Studies from the Alternatives Assessment Paradigm
Jay Tunkel, Ph.D., SRC, Inc.

Zebrafish Models for Human Organophosphorus Poisoning
Natalia Garcia-Reyero, Ph.D., U.S. Army Engineer R&D Center, U.S. Army Corps of Engineers

Session 4: Looking Ahead: Mechanisms and Adverse Outcome Pathways

Mechanisms of Acute Toxicity
Dan Wilson, Ph.D., The Dow Chemical Company

Computationally Predicted AOPs
Shannon Bell, Ph.D., Integrated Laboratory Systems, Inc.

High-throughput In Vitro Assays at NCATS
Menghang Xia, Ph.D., Division of Preclinical Innovation, National Center for Advancing Translational Sciences