DNT-DIVER: integration and visualization of DNT assay data
NIEHS Division of Translational Toxicology (DTT) launched the Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER) in 2018. DNT-DIVER allows users to analyze, compare, and visualize multiple DNT assays in an interactive web application. Initially, this resource provided data from cell-based assays and alternative animal models generated using a targeted set of 91 compounds provided by DTT. In 2019, DTT updated DNT-DIVER to allow it to be a permanent web-based application to allow public access and visualization of all data from compounds screened by the DTT’s Developmental Neurotoxicity Health Effects Innovation Program. The updated version includes different tabs including experimental design summary, quality control, chemical-specific concentration–response curves, ranking of chemical toxicity per lab/assay, and comparison of results across assays. It will also accept data from novel screening assays as they become available and accepted by the international DNT community. A testing version of DNT-DIVER was published internally in October 2023, and the resource is being modified to address team member feedback. The updated version will be launched at the SOT 2024 annual meeting.